![]() The investigators began by using a method Pasca first reported in Nature Methods in 2015. ![]() & amp amp amp amp amp nbsp Ingredients for success Lead authorship is shared by former postdoctoral scholar Omer Revah, PhD, DMV basic life research scientist Felicity Gore, PhD and psychiatry resident and postdoctoral scholar Kevin Kelley, MD, PhD. “We can now study healthy brain development as well as brain disorders understood to take root in development in unprecedented detail, without needing to excise tissue from a human brain,” said Pasca, the Bonnie Uytengsu and Family Director of Stanford Brain Organogenesis. “We can also use this new platform to test new drugs and gene therapies for neuropsychiatric disorders.” ![]() By growing and manipulating human brain tissue in the living laboratory of a rat’s brain, researchers can observe effects on the animal’s behavior, said Sergiu Pasca, MD, professor of psychiatry and behavioral sciences at the Stanford School of Medicine. 12 in Nature, demonstrates a method for performing experiments that would otherwise be invasive, difficult or impossible. The research, described in a study published online Oct. Advancing research into mental disorders and brain development, Stanford Medicine investigators have successfully connected living human nerve cells, or neurons, and supporting brain cells with the brain tissue of rats to form hybridized working circuits.
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